Abstract
Purpose: To evaluate the reliability of analysis of only 0-1min clips and 1-4min clips versus the entire clips in performing contrast-enhanced ultrasonography (CEUS) of focal liver lesions (FLLs).Methods: Contrast-enhanced ultrasonography (CEUS) examinations of 43 single FLLs were performed. All clips were analyzed in three ways, the entire clips, 0-1 min clips and 1-4 min clips, benign or malignant diagnosis and pathological diagnosis of each FLL were concluded by the three ways subsequently.Results: The results of correct diagnosis were assessed using Chi-square test. There was no difference with regard to benign or malignant diagnosis, between 0-1min clips and the entire clips, or between 1-4 min clips and the entire clips (p = 0.243 and p = 0.747, respectively). Moreover, no significant differences in pathological diagnosis existed between 0-1min clips and the entire clips, and 1- 4min clips versus entire clips (p=0.808 and p = 0.808, respectively). No significant differences existed among CEUS entire clip, 0-1min clip and 1-4min clip in identifying FLLs, and based on which the diagnosis of two different FLLs during CEUS with only one injection of contrast agent can be available.Conclusion: Only 0-1min clips or 1-4 min clips can be used to instead of the entre clip in performing CEUS of FLLs.Keywords: Focal liver lesions, Contrast-enhanced ultrasonography, Ultrasonic diagnosis, Clips
Highlights
Contrast-enhanced ultrasonography (CEUS) is a widespread imaging procedure for investigating the liver parenchyma
The study comprised 43 lesions
There were no differences with regard to benign or malignant diagnosis between 0-1min clips versus the entire clips as well as 1-4min clips versus the entire clips (p = 0.243 and p = 0.747, respectively) (Table 4)
Summary
Contrast-enhanced ultrasonography (CEUS) is a widespread imaging procedure for investigating the liver parenchyma. The portal phase lasts for 2 min after the start of injection, whereas the subsequent late phase lasts for up to 4–6 min after injection, until microbubble clearance from the liver parenchyma. Both portal phase and late phase provide information about the wash-out of focal liver lesions (FLLs) compared to the surrounding parenchyma (the term wash-out describes a transition from some enhancement of a lesion, either iso- or hyper enhancement, to a clear hypoenhancement) [3]
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