Abstract
I have established a novel approach for disrupting chemical neurotransmission rapidly and reversibly in a temporally and spatially restricted manner in the intact Drosophila nervous system. The Gal4/UAS system is used to direct expression of temperature-sensitive dynamin in restricted neuronal subsets and neurotransmission from the targeted neurons is then blocked by a mild temperature shift. This approach, together with the advanced Drosophila behavioral genetics, has provided new insight into the neuronal mechanisms underlying higher-order brain functions including associative learning and sexual orientation.
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