Abstract
Background Persistent PDA remains a common clinical presentation in preterm infants. We have already shown that high shunt volume increases LVO[1] and infants appear to have enlarged hearts (fig 1) but to what extent and their resultant function is yet unknown. The aim of this study was to quantify ventricular dimension and function in “healthy” neonates. Then compare PDA infants to this normative range to determine the impact of shunt volume. Methods Scans were performed at 3T using pediatric and extremities coils. Infants were scanned with ear protection, routine monitoring and without sedation/anesthesia. Optimized 2D SSFP short axis 10-slice stacks[2] (resolution=0.5x0.5mm, slice=4mm) were acquired. Segmentation and quantification was carried out using freely available software Segment[3], the AHA model was used for wall analysis. Description of shunt volume quantification is described
Highlights
Persistent PDA remains a common clinical presentation in preterm infants
T-tests showed significant difference in stroke volume (SV), end diastolic volume (EDV), ED wall thickness and LVmass between control and PDA infants when normalized by weight at scan
There was a significant association between shunt volume and increased LV mass when correcting for postnatal age and corrected-GA
Summary
Persistent PDA remains a common clinical presentation in preterm infants. We have already shown that high shunt volume increases LVO[1] and infants appear to have enlarged hearts (fig 1) but to what extent and their resultant function is yet unknown. The aim of this study was to quantify ventricular dimension and function in “healthy” neonates. Compare PDA infants to this normative range to determine the impact of shunt volume
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