Analysis of N-methylpyrrolidine in cefepime hydrochloride by ion chromatography using suppressed conductivity detection with solid-phase extraction pre-treatment

Abstract

N-Methylpyrrolidine (NMP) is the principal hydrolysis product of cefepime hydrochloride, a β-lactam antibiotic. Here we develop a sample preparation method for NMP in cefepime hydrochloride which significantly improves the stability of sample solutions.