Abstract
Aims: Juvenile dermatomyositis (JDM) is a rare immune-mediated microangiopathy presenting with skin lesions and proximal muscle weakness. Muscle biopsies of JDM are characterized by a reduction of endomysial capillaries and perifascicular atrophy of muscle fibers. In response to injury, normal muscle tissue has a high potential to regenerate by a process of activation, proliferation, and differentiation of satellite cells accompanied by neovascularization of regenerated muscle fibers. Little is known about muscle repair in JDM. The aim of the present study was to analyze expression of myogenic transcription factors involved in the regulation of myogenesis as well as the frequency of interstitial endothelial progenitor cells in muscle biopsies from JDM patients.
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