Abstract
BackgroundSeveral lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population.Findings546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children.ConclusionWe have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution.
Highlights
Obesity is reaching epidemic proportions worldwide and is occurring at younger ages
We have previously determined that environmental factors are associated with differences in percentage body fat (PBF) in this study group, and we have demonstrated a possible genetic contribution
This paper reports for the first time the role of Matrix metalloproteinase -2 (MMP-2) promoter polymorphisms in childhood obesity as measured using PBF
Summary
Obesity is reaching epidemic proportions worldwide and is occurring at younger ages. Body mass index (BMI) is the most common method used to determine obesity. BMI may facilitate an adult obesity diagnosis, using this method to diagnose obesity in children may yield more ambiguous results, as BMI is a marker of relative weight and doesn’t directly measure body fat [4]. Measuring percentage body fat (PBF) may be a more effective method of diagnosing obesity in children. Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population
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