Abstract

Rationale: Patients on long-term PN (parenteral nutrition) are constantly exposed to the intravenous supply of lipid emulsions, which are prone to lipid peroxidation – a chain reactions process promoted by ROS (reactive oxygen species) such as free radicals. Once initiated, lipid peroxidation causes disruption of organelle and cell membranes, deterioration of their functions and viability, and leads to inflammation. The study aimed to investigate the rate of oxygen consumption (OCR) in platelet mitochondria in patients on long-term PN and its role in the metabolism of cellular energy.

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