Abstract
BackgroundTo analyze the expression of miRNA (microRNA) in peripheral blood mononuclear cells in patients with Psoriasis vulgaris with different TCM syndromes by miRNA chip. It further revealed the micromaterial basis of different syndrome types of psoriasis at the miRNA level.MethodsPeripheral blood monocytes were collected and prepared from 30 patients with Psoriasis vulgaris (including 9 patients of blood heat syndrome, 8 patients of blood stasis syndrome, and 13 patients of blood dry syndrome) and 9 healthy controls. The miRNA expression profile of peripheral blood monocytes was detected by Agilent Hum miRNA chip.ResultsCompared to the healthy control group, 156 upregulated and 242 downregulated miRNAs were detected in all psoriasis patients. Compared to the healthy control group, 40 miRNAs were upregulated and 44 were downregulated in the blood heat syndrome group. Furthermore, there were 49 upregulated miRNAs and 44 downregulated miRNAs in the dry syndrome group as compared to the healthy control group. Also, 67 miRNAs were upregulated and 154 miRNAs were downregulated in the blood stasis syndrome group as compared to the healthy control group.ConclusionsThere are common different miRNAs and pathways, as well as specific miRNAs between the psoriasis and the healthy control groups.Trial registration ChiCTR-TRC-14005185 registered on August 8, 2014.
Highlights
To analyze the expression of miRNA in peripheral blood mononuclear cells in patients with Psoriasis vulgaris with different Traditional Chinese Medicine (TCM) syndromes by miRNA chip
Traditional Chinese Medicine (TCM) treatment of psoriasis has the advantages of a long remission period, stable condition, not easy to rebound, and less toxicity and side effects
The age of the patients was from 19 to 60 years, the duration of the disease was 1–10 years, the diagnostic standard was consistent with Psoriasis vulgaris [5], and the diagnosis of TCM syndrome was consistent with the diagnosis of bai bi syndrome [6]
Summary
To analyze the expression of miRNA (microRNA) in peripheral blood mononuclear cells in patients with Psoriasis vulgaris with different TCM syndromes by miRNA chip. It further revealed the micromaterial basis of different syndrome types of psoriasis at the miRNA level. Traditional Chinese Medicine (TCM) treatment of psoriasis has the advantages of a long remission period, stable condition, not easy to rebound, and less toxicity and side effects. In recent years, it has attracted the attention of the medical community worldwide. Blood stasis syndrome is related to a stable period, while the regression period is related to the blood dry syndrome [3]
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