Abstract
Background: We have reported the data concerning increased levels of chromosomal alterations in lymphocytes of asthmatic patients. Micronuclei (MN) represent additional nuclei formed by the exclusion of chromosome fragments at mitosis, and may reflect the approximate level of chromosome breakage in cells. Aim: The aim of the study was to determine the frequencies of MN in buccal epithelial cells of asthmatic patients. Patients and Methods: We examined 56 asthmatic patients aged 15 – 67 years. To count MN frequency (cells with MN per 100 cells) a total of 3000 buccal mucosal cells were scored per each individual. The control group consisted of 20 healthy subjects. Results: The significant (p In the cells of patients with stable asthma the MN rates in non-allergic asthmatics (0.30 ± 0.029%) appeared to be significantly (p 0.05) of MN frequencies in patients with different phenotypes. The MN rates were found to be significantly (p Conclusions: The elevated MN frequencies in cells of asthmatic patients depend on asthma phenotype and severity.
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