Abstract
Dental diseases are among the most frequent diseases of the human body. The microflora of the oral cavity is specific, unlike the microflora of other cavities both in composition, quantity, and functions. The resident microflora will play an important role both in maintaining the normal physiological state of the oral cavity and in the development of dental diseases.
 The aim of the study is to establish insemination with clinically significant microorganisms of oral fluid in patients with defects of dentition, Zakarpattia region residents.
 The species and quantitative composition of microbiocenosis of the oral fluid of 282 (94 men and 188 women) patients with dentition defects, residents of the Zakarpattia region, confirms the formation and progression of inflammatory and inflammatory-dystrophic changes in the periodontal tissues.
 In patients with bilateral end defects according to Kennedy, the predominance of anaerobic microflora was determined in the form of Klebsiella pneumonia (108), Prevotella spp. (7×105), Enterobacter spp. (102), Porphyromonas spp. (5×105), Staphylococcus epidermidis (104) and Staphylococcus aureus (1,2×103), Streptococcus pneumonia (108), Streptococcus viridans (103), Enterobacter spp. (102) and opportunistic microorganisms Candida albicans (104).
 Among patients with unilateral end defects according to Kennedy, Enterococcus faecalis was defined. (103), Staphylococcus epidermidis (102–103) and Staphylococcus aureus (105), Streptococcus pneumonia (105–107), Streptococcus viridans (102–5×105), Stahylococcus haemolyticus (102), Candida albicans (5×102) and Escherichia coli coli (109).
 In patients with included defects in the lateral areas according to Kennedy, there were cultured Klebsiella pneumonia (101–3.5×106), Prevotella spp. (4-5×101), Enterococcus faecalis (107), Peptostreptococcus micros (3.5×103–5×103), Staphylococcus haemolyticus (101–105) and Staphylococcus aureus (101–105), Streptococcus pneumonia (106–108 ), Streptococcus pyogenes (105–109), Candida albicans (102), Escherichia coli (107), Sarcina spp. (103) and Citrobacter spp. (104).
 Microbiocenosis of the oral fluid of the fourth clinical group with included defects in the frontal areas according to Kennedy is presented Lactobacillus acidophilus (108-1011), Streptococcu mitis (108-1011), Bifidobacterium (108-1010), Streptococcus salivarius (1081010), Streptococcus mutans (107-109), Streptococcus pneumonia (104 –108), Streptococcus sanguis (105–107).
 Therefore, in patients with dentition defects, the microflora of the oral fluid confirms the formation of inflammatory and inflammatory-dystrophic processes in the periodontal tissue due to the prevalence of anaerobic flora, while in the presence of inclusions in the frontal area, the prevalence of normal obligate microflora is diagnosed.
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