Abstract
Human bone cells live in a complex environment, and the biomimetic design of porous structures attached to implants is in high demand. Porous structures based on Voronoi tessellation with biomimetic potential are gradually used in bone repair scaffolds. In this study, the mechanical properties and permeability of trabecular-like porous scaffolds with different porosity levels and average apertures were analyzed. The mechanical properties of bone-implant scaffolds were evaluated using finite element analysis and a mechanical compression experiment, and the permeability was studied by computational fluid dynamics. Finally, the attachment of cells was observed by confocal fluorescence microscope. The results show that the performance of porous structures can be controlled by the initial design of the microstructure and tissue morphology. A good structural design can accurately match the performance of the natural bone. The study of mechanical properties and permeability of the porous structure can help address several problems, including stress shielding and bone ingrowth in existing biomimetic bone structures, and will also promotes cell adhesion, migration, and eventual new bone attachment.
Highlights
In China, 15 million patients with bone defects need artificial bone tissue each year (Attar et al, 2018)
We propose a controllable irregular porous structure method based on probability balls and the Voronoi–Tessellation approach (Du et al, 2020)
The curves show that the porous structure of titanium alloy exhibits no apparent yield behavior
Summary
In China, 15 million patients with bone defects need artificial bone tissue each year (Attar et al, 2018). Porous scaffolds play an important role in the proliferation and differentiation of human cells. Porous scaffolds play an important role in nutrient transport and waste removal during cell growth. Trabecular bones are Permeability Analysis of Trabecular-Like Scaffold arranged in the same direction as that of bone stress and tension and can bear larger weights. It provides a template for constructing artificial bone scaffolds (Feng et al, 2017; Alias and Buenzli, 2018; Zhang et al, 2019)
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