Abstract
This paper demonstrates a low cost fabrication approach for microscale droplet fission and encapsulation. Using a modified xurography method, rapid yet reliable microfluidic devices with flexible designs (single layer and double layer) are developed to enable spatial control of droplet manipulation. In this paper, two different designs are demonstrated, i.e., droplet fission (single layer) and droplet encapsulation (double layer). In addition, the current fabrication approach reduces the overall production interval with the introduction of a custom-made polydimethylsiloxane (PDMS) aligner. Apart from that, the fabricated device is able to generate daughter droplets with the coefficient of variance (CV) below 5% and double emulsions with CV maintained within 10% without involvement of complex surface wettability modification.
Highlights
Droplet microfluidics, one subcategory under microfluidics, enable the manipulation of fluid in the discrete form such as micro-droplets that offers greater benefits than the conventional flow systems in terms of high throughput and scalability
This paper proposes a modified xerographic method by which a PDMS-Glass hybrid microfluidic device is fabricated enabling the process of droplet encapsulation to be carried out under consistent wall surface properties
In order to test on the increased accuracy and efficiency of the cutter plotter of theoptimization cutter plotter optimization for xurography technique, theused microchannel widths in after forafter xurography technique, the microchannel widths in this study wereused mainly this study were mainly drawn in μm
Summary
One subcategory under microfluidics, enable the manipulation of fluid in the discrete form such as micro-droplets that offers greater benefits than the conventional flow systems in terms of high throughput and scalability. Droplet fission is known as a simpler way to introduce multiple sample arrays for rapid mixing or chemical reaction while increasing the throughput for droplet production and digitizing the biological assays at the same time [8], whereas controlled micro-encapsulation or better known as double emulsions provides a high entrapment efficiency and desired particle size [9]. A range of materials [11,12,13,14] has been reported to successfully fabricate the microfluidic device with different fabrication techniques developed.
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