Abstract
AIM: to analyze functional state of kidneys in women with urinary incontinence. PATIENTS AND METHODS: 277 women with complaints on urinary incontinence and 14 healthy women aged 18 to 55 years were examined. 143 women was diagnosed stress urinary incontinence, 43 – urge urinary incontinence and 91 – mixed urine incontinence. Nycturia was revealed in 24 women and polyuria – in 60 women with urine incontinence. The increased diuresis, water reabsorption in collecting ducts, ion excretion including Na and Mg ion were higher during the night in patients with nycturia and during the day in patients with polyuria in comparison with healthy patients. Use of desmopressin (minirin) in a dose of 100 mcg reduced diuresis and ion excretion to normal levels. It is suggested that the main role in the pathogenesis of kidney functions in patients with polyuria and nycturia is played by a decrease of ion reabsorption in the thick ascending Henle loop, which results in higher load of collecting ducts by liquid, increase of diuresis and electrolytes excretion. Use of desmopressin in these patients is pathogenetically proved because it removes main tubular defect.
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