Abstract
Metronidazole is an antibiotic and useful for the antibacterial and antiprotozoal medication. This study was performed to investigate the impact of the Trivedi Effect®-Biofield Energy Healing Treatment on the structural properties and the isotopic abundance ratio of metronidazole using LC-MS and GC-MS spectroscopy. Metronidazole sample was divided into two parts, one part of metronidazole was considered as control (no Biofield Energy Treatment was provided), while the second part was treated with the Trivedi Effect®-Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton and termed as a treated sample. The LC-MS spectra of both the samples of metronidazole at the retention time (Rt) 2.61 minutes exhibited the mass of the protonated molecular ion peak at m/z 172 M+H+ (calculated for C6H10N3O3+, 172.07). The LC-MS based isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 15N/214N or 17O/16O) in the treated metronidazole was significantly increased by 8.24% compared with the control sample. Thus,13C, 2H, 15N,and17O contributions from (C6H10N3O3)+ to m/z 173 in the treated sample were significantly increased compared with the control sample. The GC-MS based isotopic abundance ratio of PM+1/PM in the treated metronidazole was significantly increased by 5.92% compared with the control sample. Hence,13C, 2H, 15N, and217O contributions from (C6H9N3O3)+ to m/z 172 in the Biofield Energy Treated sample were significantly increased compared with the control sample. However, the isotopic abundance ratio of PM+2/PM in the treated metronidazole was significantly decreased by 18.2% compared with the control sample. Hence,18O contributions from (C6H9N3O3)+ to m/z 173 in the treated sample were significantly decreased compared with the control sample. The isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 15N/14N or 17O/16O) and PM+2/PM (18O/16O) in the treated metronidazole was significantly altered compared to the control sample. From the results, it can be hypothesized that the changes in isotopic abundance and mass peak intensities could be due to changes in nuclei possibly through the interference of neutrino particles via the Trivedi Effect® - Consciousness Energy Healing Treatment. The new form of treated metronidazole would be better designing novel pharmaceutical formulations that might offer better therapeutic response against bacterial and protozoal infection in the vagina (bacterial vaginosis), stomach (giardiasis, trichomoniasis, pseudomembranous colitis), joints (pelvic inflammatory disease), liver, skin, brain, and respiratory tract, aspiration pneumonia, rosacea, intra-abdominal infections, lung abscess, fungating wounds, periodontitis, amoebiasis, oral infections, etc.
Highlights
Metronidazole is an antibiotic, useful for the antiprotozoal medication
The percentage change of the isotopic abundance ratio (PM+1/PM) in the Biofield Energy Treated metronidazole was significantly increased by 8.24% compared with the control sample (Table 1)
The LC-mass spectrometry (MS) and gas chromatography - mass spectrometry (GC-MS) based isotopic abundance ratios of PM+1/PM (2H/1H or 13C/12C or 15N/14N or 17O/16O) and PM+1/PM % Change of isotopic abundance ratio (PM+2/PM) (18O/16O) in the Biofield Energy Treated metronidazole were significantly altered compared to the control sample
Summary
Metronidazole is an antibiotic, useful for the antiprotozoal medication. The mechanism of action involves the inhibition of the microorganism by means of disrupting the DNA of microbial cells for the nucleic acid synthesis. This function only occurs when metronidazole is partially reduced, which usually happens only in anaerobic cells [1, 2] It is useful for the treatment of bacterial infections in the vagina (bacterial vaginosis), stomach (giardiasis, trichomoniasis, pseudomembranous colitis), liver, skin, joints (pelvic inflammatory disease), brain, and respiratory tract, aspiration pneumonia, rosacea, fungating wounds, intraabdominal infections, lung abscess, periodontitis, amoebiasis, oral infections, and infections caused by susceptible anaerobic organisms such as Bacteroides, Dracunculus, Clostridium, Peptostreptococcus, Fusobacterium, Helicobacter pylori, and Prevotella species, etc. The solubility profile of metronidazole is very poor, where is very slightly soluble in cold water, hot water, alcohol, chloroform, dilute acid, and dimethylformamide [9, 10]
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More From: Journal of Advanced Pharmaceutical Science And Technology
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