Analysis of Intestinal Flora and Levels of Epidermal Growth Factor Receptor, Interleukin-32, and Gastrin 17 in Patients with Gastric Cancer via Carbon Nanoparticle Laparoscopy.

Liping Bai,Peng Li,Yinhui Zhang,Zhijian Ma,Zhi Li,Lixian Bai,Xueyan Yang,Fubing Yu,Zhenbo Xu

doi:10.1155/2021/6697597

Abstract

In order to explore the changes of intestinal flora and serum levels of relevant substances in patients with gastric cancer before and after surgery with carbon nanoparticle laparoscopy, a total of 180 patients with early distal gastric cancer who adopted laparoscopic radical gastrectomy for distal gastric cancer in the general surgery department of TCM Hospital of Shi Jia Zhuang City from January 2018 to January 2020 were selected and randomly divided into two groups: traditional laparoscopic operation (control group) and carbon nanoparticle laparoscopic operation (experimental group) were adopted for treatment for the two groups, respectively. Postoperative evaluation included the difference between the two groups in the operative time, the efficiency of intraoperative lymph node dissection, and the number of lymph node detection. The adverse reactions, changes of intestinal flora before and after surgery in the two groups, and the serum levels of epidermal growth factor receptor (EGFR), interleukin-32 (IL-32), and gastrin 17 were evaluated. In the experimental group, the success rate of carbon nanoparticle tracer black staining reached 100%, and the operation time of the experimental group was significantly shorter than that of the control group (P < 0.05). The lymph node detection rate of the experimental group was higher than that of the control group (P < 0.05), but there was no significant difference in the lymph node metastasis rate between the two groups (P > 0.05). The sentinel lymph node sensitivity of the experimental group reached 92.3%, and the specificity, accuracy, and positive and negative prediction rates reached 100%; the experimental group patients were with an obviously higher incidence of level I-II gastrointestinal reaction (P < 0.05). Postoperative increases in Bifidobacteria and Lactobacillus were observed in both groups, while decreases in Enterococcus and Escherichia coli were observed in both groups (P < 0.05). Moreover, the degree of increase and decrease in the experimental group was greater than that in the control group (P < 0.05). The serum levels of EGFR, IL-32, and gastrin 17 in the two groups were significantly lower than those in the control group on 3 d, 7 d, and 15 d after surgery (P < 0.05). In the radical gastrectomy for distal gastric cancer, carbon nanoparticle laparoscopy was not only helpful for the localization of small tumors but also for the thorough dissection of lymph nodes after the surgery, and the postoperative adverse reactions of carbon nanoparticle laparoscopy were also less, which was of great significance for the improvement of intestinal flora and the reduction of serum levels of EGFR, IL-32, and gastrin 17 in gastric cancer patients.

Highlights

Gastric cancer is one of the four most common malignant tumors in the world, and its fatality rate ranks the top seven.It can be seen in the gastric antrum, the greater and lesser curvature of the stomach, and the anterior and posterior walls
No adverse reactions or suspected adverse reactions were found in the experimental group
The adverse reactions, intestinal flora, and serum levels of epidermal growth factor receptor (EGFR), IL-32, and gastrin 17 in the two groups were compared and evaluated before and after the operation; it was found that the postoperative adverse reactions were more obvious in the control group than those in the experimental group

Summary

Introduction

Gastric cancer is one of the four most common malignant tumors in the world, and its fatality rate ranks the top seven.It can be seen in the gastric antrum, the greater and lesser curvature of the stomach, and the anterior and posterior walls. Gastric cancer is one of the four most common malignant tumors in the world, and its fatality rate ranks the top seven. BioMed Research International are estimated to be nearly 700,000 new cases of gastric cancer in China every year, and the mortality rate is about 500,000, ranking the second in both the incidence and mortality of malignant tumors [1]. For patients with early gastric cancer, it can perform radical gastrectomy I, which can effectively remove the first group of lymph nodes around the stomach. For patients with advanced gastric cancer, radical gastrectomy type II can be performed, which can completely remove the second group of lymph nodes. For gastric cancer patients with lymph node metastasis in group 3, radical gastrectomy III should be adopted, which can completely remove lymph node metastasis in group 3 and obtain the best therapeutic effect

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