Abstract
Objective To study the situation of nosocomial infection and drug resistance of acinetobacter baumanniinii (ABA) at a neurosurgical center. Methods A retrospective analysis was conducted about the data of ABA and its rate of drug resistance from the inpatients at Department of Neurosurgery, the First Affiliated Hospital of Army Military Medical University from January 2012 to September 2017. The minimum inhibitory concentration method was used to compare the resistance of ABA to 21 common antibiotics. The change trend of drug resistance of ABA in the past 6 years was analyzed. Results A total of 1420 strains of ABA were isolated from 2012 to 2017. During the past 6 years, ABA detected at Department of Neurosurgery accounted for 10.7%-23.9% of the total bacteria detected. The proportion of ABA detected at Department of Neurosurgery was higher than that at the whole hospital (8.4%-14.3%). Except for 2014, the difference was statistically significant in 2012, 2013, 2015 and 2017 (P 90.0%) and piperacillin (65.3%-88.2%) of penicillins was maintained at a high level for 2013-2017 years (P < 0.01), but the resistance of penicillin with enzyme inhibitor, such as ampicillin-sulbactam (62.0%-80.7%) and piperacillin-tazobactam (65.5%-78.0%), was relatively low. Compared with ampicillin and piperacillin, the difference was statistically significant (P < 0.001). After 2013, the resistance rates of ABA to cephalosporins, imipenem and meropenem exceeded 65%. The resistance rate of ABA to cefoperazone-sulbactam increased gradually and exceeded 50% after 2015. The proportion of multidrug-resistant ABA was also increasing year by year from 2012 to 2017 (36.3%-82.0%, P=0.000). Conclusions The proportions of ABA infection and its drug resistance at Department of Neurosurgery seem to be increasing. We should pay attention to prevention and control of those. Antibiotics need to be administered rationally with reference to the results of bacterial susceptibility. Key words: Acinetobacter baumannii; Cross infection; Drug resistance
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