Analysis of Hypoxia-Inducible Factor-1a and Intercellular Adhesive Molecule-1 on Clinical Findings in Rhegmatogenous Retinal Detachment Patients

Abstract

The aim of the study is to examine the role of hypoxia-inducible factor-1a (HIF-1a) and intercellular adhesive molecule (ICAM-1) in clinical findings found in patients with rhegmatogenous retinal detachment (RRD). The clinical findings are; the duration of retinal detachment, retinal quadrants involvement, and the severity of proliferative vitreoretinopathy (PVR). A cross sectional study was conducted, with 34 consecutive vitreous sample were obtained from dr. Cipto Mangunkusumo National General Hospital (RSCM), from October 2015 to October 2016. The samples were taken from RRD patient who received vitrectomy in the hospital. There were no significant difference between the ICAM-1 and HIF-1a levels to the clinical findings that is measured; duration of retinal detachment (p>0.05), extent of retinal detachment area (p>0.05) and severity of PVR (p>0.05). However, there is a significant mean difference of ICAM-1 level on the duration of retinal detachment, where < 1 week group has higher mean 49.71, (SD 49.54) than the other group, as well as in the retinal quadrants groups (2nd quadrant 19.42 (SD 2.49) and also in severity of PVR groups (PVR B 35.42, SD 30.13). The results from HIF-1a level on each sub group were insignificant. The level of ICAM-1 and HIF-1a cannot be used as predictor of the clinical findings found in the patients. ICAM-1 levels tend to be high on patients whose diagnosed with retinal detachment early, with smaller area of detachment (2nd quadrant) and lower PVR levels (PVR B). The level of HIF-1a shows a consistent pattern with minimal difference in between the sub groups.