Abstract
Investigations to assess the state of the reproductive system in female rats in experimental streptozotocin (STZ)-induced diabetes have been a logical continuation of studies we have carried out previously [4, 5] to analyze the interrelationship of disturbances of the reproductive system and sexual behavior in male rats in diabetes. It is known that by contrast with males, cyclical changes in the activity of the reproductive system are characteristic for females. Consequently, it is not excluded that the differences observed in the norm in the regulation of the gonadotropic function of the hypophysis in male and female rats may explain the fact that males are in the main more sensitive to the hyperglycemic action of STZ than females [13]. In addition, some data point to nonidentical changes in the organism of males and females in the presence of an insulin deficit [10]. Bestetti et al. [7] have concluded, on the basis of the results of morphological and physiological investigations, that changes in the hypophysis are less clearly manifested in the females than the males. The interpretation of the results obtained by various investigators when studying the reproductive system in diabetic females has been complicated by the presence of cyclical changes.
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