Abstract
Analysis of HLA antigens was performed in 42 Japanese patients with oral lichen planus (OLP). There were no significant differences in the frequency of HLA-A, B, C antigens between OLP-patients and control subjects, although a decreasing trend in the frequency of Bw 52 and an increasing trend in that of Bw 61 and Cw 3 was noted. Among the HLA-DR and DQ antigens studied, the frequency of DRw 9 was significantly increased (Pc less than 0.05, RR = 3.3) and the relative risk was increased (RR = 6.0) when DRw 9 was carried on as a Bw 61/DRw 9 haplotype. Our results suggest that HLA-associated genetic factors play a role to some extent in the development of OLP.
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