Abstract
SummaryMiddle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity with highly invasive properties causing bone destruction and it may lead to complications. Aim: To study the histopathological features in acquired cholesteatomas of the middle ear, correlating this data with patient age. Study design:clinical and experimental cross-sectional study. Material and Methods: Samples were obtained from 50 patients submitted to otologic surgery for the removal of middle ear cholesteatomas from 2006 to 2007. Thirty four patients were adults and 16 were children. Samples were studied by histological analysis. Results: we found the presence of epithelial atrophy (78%), epithelial acanthosis (88%), hyperplasia of the basal layer (88%) and formation of epithelial cones (62%). There was a positive and significant correlation between histopathological variables (such as epithelial acanthosis, hyperplasia of the basal layer and formation of epithelial cones). Histopathological variables presented no statistical significant difference in both age groups (p>0,05). Conclusion: Cholesteatomas have hyperproliferating characteristics with epithelial acanthosis, hyperplasia of the basal layer and the presence of epithelial cones in the matrix.
Highlights
Middle ear cholesteatomas are characterized by the presence of keratinized squamous stratified epithelium inside the cavity
Acquired middle ear cholesteatoma is a hyperproliferative disease accompanied by acanthosis, basal layer hyperplasia, and formation of epithelial cones in the matrix and inflammatory processes in the perimatrix
The more acanthosis was found in the cholesteatoma matrix, the greater was basal layer hyperplasia
Summary
Middle ear cholesteatomas are characterized by the presence of keratinized squamous stratified epithelium inside the cavity. Cholesteatoma epithelium has the four layers usually observed in thin skin epidermis, namely basal, squamous, granulous, and stratum corneum, and is called cholesteatoma matrix. Cholesteatomas are a common occurrence in our area, but are rare entities in other countries, as they amount to 0.1% to 0.5% of all middle ear diseases. The ratio of men and women with disease is 1.2: 1.0 with ages ranging from 3 to 70 years[2]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
