Abstract
Analysis of Histologic Parameters Associated with Nuclear Size in Diffuse Malignant Peritoneal Mesothelioma Uniformly Treated by Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy
Highlights
Several studies have documented that diffuse malignant peritoneal mesothelioma (DMPM) consists of heterogeneous histopathologic features [1,2,3]
Cerruto and colleagues used a group of 62 DMPM patients treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy to search for histologic parameters that correlated with prognosis [5]
The current study attempts to identify other histologic features that can act as an adjunct to nuclear size in the histopathologic estimation of prognosis in DMPM patients to be treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy
Summary
Several studies have documented that DMPM consists of heterogeneous histopathologic features [1,2,3]. Nonaka and co-workers demonstrated an improved survival in patients with low-grade nuclei after cytoreductive surgery and perioperative intraperitoneal chemotherapy [4]. Cerruto and colleagues used a group of 62 DMPM patients treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy to search for histologic parameters that correlated with prognosis [5]. In this study they identified nuclear/nucleolar size as the most reliable single parameter by which to predict outcome. The current study attempts to identify other histologic features that can act as an adjunct to nuclear size in the histopathologic estimation of prognosis in DMPM patients to be treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy
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