Abstract
It has been suggested that squamous cell carcinoma (SCC) in young patients is a distinct disease from that occurring in older patients. Retrospective samples of young and adult patients diagnosed with SCC of the tongue and floor of the mouth were selected. Histopathological analysis was performed using the World Health Organization (WHO) grading system and histopathological risk assessment. Immunohistochemical staining was used to evaluate the expression of HER-1, HER-2, and p16. Younger patients were classified as having a high risk for recurrence. All cases were immunopositive for HER-1 and 100% of the sample was negative for HER-2. The p16 immunostaining was greater for younger patients. HER-1 showed an important role in the carcinogenesis of SCC of the tongue and floor of the mouth.
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