Analysis of heart rate response to maximal expiratory pressure and Valsalva maneuver in healthy young men

Abstract

s / Autonomic Neuroscience: Basic and Clinical 163 (2011) 1–133 46 per day to achieve the goal BP. The repeat estimation of BRS was performed in 6 months of treatment. Results: At baseline spontaneous BRS in RHTN was significantly lower compared to controls (5.61±0.08 vs 6.60±0.10 ms/mm Hg; P<0.05). Inhypertensive patients baseline spontaneousBRSnegatively correlated with the mean 24 hour SBP (r=−0.48; P=0.02) and mean 24 hour DBP (r=−0.44; P=0.04) BP at baseline. Hypertensive patients were subdivided on two groups: who took spironolactone 25 mg per day (group 1, n=26) andwho took spironolactone 50 mg per day (group 2, n=8). SpontaneousBRSatbaselinewas similar inbothgroups. In “high” spironolactone dose patients final 24 hour SBP and 24 hour DBP were lower than similar values in “low” dose spironolactone patients (126± 3/83±2 vs 134±4/89±1 mm Hg; P<0.01). In patients of group 2 the final BRS was higher compared with patients of group 1 (6.30±0.07 vs 5.80±0.08 ms/mm Hg; P<0.05). The negative correlations of BRS delta with SBP delta (r=−0.53; P=0.02) and DBP delta (r=−0.44; P<0.05) were observed only in patients of group 2. Conclusion: In patients with RHTN, spontaneous BRS is decreased and is negatively associated with the level of BP. Combinative antihypertensive treatment with spironolactone improves spontaneous BRS in patients with RHTN.