Abstract
Capillary electrophoretic methods, under MEKC conditions, were developed for thesimultaneous rapid analysis of neutral (guaifenesin) and basic (salbutamol and dex-tromethorphan) active ingredients of commercially available cough syrups. The run-ning buffer nature played a key role on the migration of the studied analytes: using0.04 M sodium dodecyl sulfate (SDS) as surfactant, sodium tetraborate and 3-(cyclo-hexylamino)-2-hydroxy-1-propane-sulfonic acid sodium salt (CAPSO) were chosenas running buffer allowing the separation of active ingredients and excipients of differ-ent cough syrups. Qualitative and quantitative information on the composition of theanalyzed formulations were simultaneously obtained for both active ingredients andexcipients by the proposed MEKC methods; when syrups containing volatile UV-non-absorbing components (flavors) were analyzed a GC-MS approach was chosen. Theaqueous matrices of the formulations allowed direct sample injection in CE, whileextraction procedures were applied in order to perform GC analyses. The obtaineddata support the suitability of MEKC and GC-MS as effective, complementary techni-ques for the selective and sensitive quality control of cough syrups.Key Words: Cough syrups; Capillary electrophoresis; GC-MS; Guaifenesin; Salbuta-mol;DextromethorphanMs received: January 10, 2001; revised Ms received: February 16, 2001; accepted:February17,2001
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