Analysis of GluR1 expression in Basigin null mouse brains

Abstract

Event Abstract Back to Event Analysis of GluR1 expression in Basigin null mouse brains Gerard Ardoin1* and Judith D. Ochrietor1 1 Swedish Defence Research Agency, Faculty of Electrical Engineering and Computing, United States Basigin null mice are characterized as having learning and memory deficiencies, as well as other neurological abnormalities. GluR1 is a member of the glutamate-gated ion channel family and functions as a subunit of AMPA receptors, which are involved in long-term potentiation. The purpose of this study was to examine membrane-expression of GluR1 in Basigin null mice and littermate controls. Enzyme Linked Immunosorbent Assays (ELISAs) were performed on detergent lysates from normal and Basigin null mouse brains using an antibody specific for GluR1. It was determined that membrane-associated expression of GluR1 in Basigin null mouse samples was similar to that of the controls. The data suggest that synaptic plasticity mediated via AMPA receptors is not impaired in Basigin null mouse brains. Future studies will examine other molecular components of synaptic plasticity in Basigin null mouse brains in an attempt to determine the mechanism underlying the learning and memory deficiencies observed in those animals. Conference: 2010 South East Nerve Net (SENN) and Georgia/South Carolina Neuroscience Consortium (GASCNC) conferences, Atlanta , United States, 5 Mar - 7 Mar, 2010. Presentation Type: Poster Presentation Topic: Posters Citation: Ardoin G and Ochrietor JD (2010). Analysis of GluR1 expression in Basigin null mouse brains. Front. Neurosci. Conference Abstract: 2010 South East Nerve Net (SENN) and Georgia/South Carolina Neuroscience Consortium (GASCNC) conferences. doi: 10.3389/conf.fnins.2010.04.00021 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Mar 2010; Published Online: 15 Mar 2010. * Correspondence: Gerard Ardoin, Swedish Defence Research Agency, Faculty of Electrical Engineering and Computing, Kista, United States, gerard.ardoin@unf.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gerard Ardoin Judith D Ochrietor Google Gerard Ardoin Judith D Ochrietor Google Scholar Gerard Ardoin Judith D Ochrietor PubMed Gerard Ardoin Judith D Ochrietor Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.