Abstract
BackgroundIn recent years, several genomic regions have been robustly associated with coronary artery disease (CAD) in different genome-wide association studies (GWASs) conducted mainly in people of European descent. These kinds of data are lacking in African populations, even though heart diseases are a major cause of premature death and disability.MethodsHere, 384 single nucleotide polymorphisms (SNPs) in the top four CAD risk regions (1p13, 1q41, 9p21, and 10q11) were genotyped in 274 case-control samples from Morocco and Tunisia, with the aim of analyzing for the first time if the associations found in European populations were transferable to North Africans.ResultsThe results indicate that, as in Europe, these four genetic regions are also important for CAD risk in North Africa. However, the individual SNPs associated with CAD in Africa are different from those identified in Europe in most cases (1p13, 1q41, and 9p21). Moreover, the seven risk variants identified in North Africans are efficient in discriminating between cases and controls in North African populations, but not in European populations.ConclusionsThis study indicates a disparity in markers associated to CAD susceptibility between North Africans and Europeans that may be related to population differences in the chromosomal architecture of these risk regions.
Highlights
Cardiovascular disease (CVD) continues to be the leading cause of mortality and morbidity in Western populations.[1]
15 single nucleotide polymorphisms (SNPs) were not successfully genotyped, 1 SNP showed a significant departure from Hardy-Weinberg equilibrium after Bonferroni correction, and 19 SNPs failed the frequency test (MAF
A total of 349 markers were included in the analyses after quality control: 57 SNPs in 1p13, 36 in 1q41, 148 in 9p21, and 108 in 10q11
Summary
Cardiovascular disease (CVD) continues to be the leading cause of mortality and morbidity in Western populations.[1]. Several genomic regions have been robustly associated with coronary artery disease (CAD) in different genome-wide association studies (GWASs) conducted mainly in people of European descent. These kinds of data are lacking in African populations, even though heart diseases are a major cause of premature death and disability. Conclusions: This study indicates a disparity in markers associated to CAD susceptibility between North Africans and Europeans that may be related to population differences in the chromosomal architecture of these risk regions
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