Abstract
The human brain is one of the most mysterious tissues in the body. Our knowledge of the human brain is limited due to the complexity of its structure and the microscopic nature of connections between brain regions and other tissues in the body. In this study, we analyzed the gene expression profiles of three brain regions—the brain stem, cerebellum and cerebral cortex—to identify genes that are differentially expressed among these different brain regions in humans and to obtain a list of robust, region-specific, differentially expressed genes by comparing the expression signatures from different individuals. Feature selection methods, specifically minimum redundancy maximum relevance and incremental feature selection, were employed to analyze the gene expression profiles. Sequential minimal optimization, a machine-learning algorithm, was employed to examine the utility of selected genes. We also performed a literature search, and we discuss the experimental evidence for the important physiological functions of several highly ranked genes, including NR2E1, DAO, and LRRC7, and we give our analyses on a gene (TFAP2B) that have not been investigated or experimentally validated. As a whole, the results of our study will improve our ability to predict and understand genes related to brain regionalization and function.
Highlights
Human brains are distinguished from those of all other species by their incomparable cognitive capacities
These curves show that for a given training dataset and test dataset, the feature set yielding the maximum value for total prediction accuracy on the test dataset can be obtained, and the numbers of features in these sets are listed in S3 Table
This study investigated the gene expression profiles of three human brain regions from six people of different races, ages, and sexes
Summary
Human brains are distinguished from those of all other species by their incomparable cognitive capacities. Throughout human history, people have questioned how this mysterious and powerful organ functions in such a highly orchestrated manner. Studies of the human brain using cellular and molecular biological techniques have been undertaken for generations, but the mechanisms underlying the development, differentiation and function of the human brain remain quite elusive. It is widely accepted that fine-tuned spatiotemporal gene expression. Analysis of Gene Expression Profiles of Human Brain
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