Abstract
The human leukemia K562—n cell line displays much higher tumorigenic actively in nude mice compared with its parental K562 cell line. The molecular mechanism of the differences in tumorigenicity between K562-n and K562 in nude mice was examined. The differences in gene expression between K562 and K562-n cells were analyzed by using cDNA microarrays. Among the12,800 genes examined, there was a significant difference in expression of 139 genes between K562—n and K562 cells. Eighty—five of these genes have been registered in the GeneBank and 54 are unknown. The genes accessible from the GeneBank include: 1) oncogenes and tumor—supressor genes; 2) genes related to transcription regulation, the cell cycle and apoptosis; 3) genes related to the cytoskeleton and cytokinetics; 4) genes related to metabolism and transport; 5) genes related to immune function. There were also some differently expressed genes with mixed functions. There are many genes differentially expressed between K562—n and K562 cells The high tumorigenicity of the human leukemia K562—n cell line in nude mice might be related to its specific gene-expression profile.
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