Analysis of Gene Expression in Intracranial Aneurysms

Abstract

Abstract INTRODUCTION Different gene expression profiles are observed in intracranial aneurysm tissue. Understanding these genes and what regulates their expression will help us to understand intracranial aneurysm pathogenesis. We investigated whether there are differences in gene expression in intracranial aneurysms. METHODS A total of 16 intracranial aneurysm tissues were compared with 16 matched samples from the superficial temporal artery as controls. We detected the gene expression profiles in these samples with the Human U133 Plus 2.0 GeneChip. RESULTS A total of 2357 differentially expressed gene transcripts were detected based on the gene expression profile. Verification analysis showed that the VCAM1, MAGI2, PPP2R2B, PPP2R3A genes were associated with the occurrence and development of intracranial aneurysm. These genes mainly encode cell adhesion molecules (CAMs) and ERK/JNK signaling pathways. CONCLUSION Changes of genes expression involved in immune and inflammatory reactions, CAMs may be associated with the development of aneurysms.