Abstract
The strategy of an STR and SNP combined system has been suggested to reduce the costs and procedures of genotyping and shows great value in kinship testing. In this study, in order to test how many markers are sufficient to perform the kinship testing for siblings, 60 STRs, 30 insertions and deletions (InDels), and 472 SNPs were collected. The specificity for distinguishing full-siblings was no less than 99.99% under a false discovery rate (FDR) of 0 when at least 57 out of the 60 STRs were used. The specificity for distinguishing half-siblings was 99.93% under a FDR of 0 when all the markers were used. In total, the combined marker system showed promise for solving the problem of sibling relationship identification.
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