Abstract

A major issue in systems biology, which is well studied in control theory, is the analysis of feedback circuits in a dynamical system. These circuits endow biological systems with required functional properties. We give an overview on recent research results for the analysis of feedback circuits in cell-biological systems using methods from control theory. Starting from the known functional roles of feedback circuits, we summarize the biological questions that motivate a control theoretical analysis and perspective. Then, suitable methods for such an analysis are presented. We discuss how to apply these methods to biological research problems by summarizing different research projects that deal with feedback circuits in cell-biological systems.

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