Analysis of factors related to axillary non sentinel lymph node metastasis in breast cancer patients with positive sentinel lymph node

Abstract

Objective To investigate the related factors of axillary non-sentinel lymph node (NSLN) metastasis in breast cancer patients with positive sentinel lymph node (SLN). Methods Ninety-eihgt patients with breast cancer, who were SLN positive according to sentinel lymph node biopsy (SLNB) and underwent axillary lymph node dissection (ALND) successfully in Shanxi General Hospital from March 2017 to March 2018, were selected as research objects. Thirty-two patients were allocated into NSLN positive group, and 66 patients were allocated into NSLN negative group according to the axillary NSLN condition. The relationship between the clinical indexes and pathological indexes and the axillary NSLN metastasis of breast cancer was analyzed by univariate factor analysis and multivariate factor Logistic regression analysis. Results The number of SLN and number of NSLN positive in NSLN positive group were slightly higher than those in NSLN negative group, but the difference was not statistically significant (P>0.05); and number of SLN positive and number of NSLN in NSLN positive group were significantly higher than those in NSLN negative group (P 1, P<0.05). Conclusions High grade of histology, ER+ , PR+ , no amplificayion of HER-2, vascular embolism, 2 cases of SLN positive and Luminal B molecular type are independent risk factors of breast tumor NSLN metastasis. Key words: Breast cancer; Sentinel lymph node positive; Axillary non sentinel lymph node metastasis; Risk factors