Analysis of factors of congenital malformations in families where there were cases of infertility in anamnesis

Abstract

Analyses of clinical, epidemiological, medical and statistical data of source documents over the period of 2010-2013 have been carried out prospectively. The data were selected using the method "case-control", namely, registration forms of couples with infertility cases in anamnesis. For each registered case of infertility "Registration Card of primary infertility" was filled in and, as a control, "Registration card of a couple who gave birth to alive full-term healthy baby" born in the shortest period of time (according to methodical recommendations "The organization of genetic monitoring" [13]. 3 women (10,0 %) with primary infertility who contacted with occupational hazards (masters of tailoring services who suffered from noise and vibration) and no such cases in women in the control group (p<0,05). In women, of the studied group in 66,7 % of cases were observed gynecological diseases: Hydrosalpinx and saktosalpinks – 9 patients (30,0 %), 5 – Ovarian cysts (16,7 %), 3 – Ovarian sklerokistoza (10,0 %) and recorded one case of ovarian tuberculosis (3,3 %), that is statistically different (p<0,05) from the data of the control group – in which only two patients had ovarian cysts (6,7 %). In the studied group 17 women (56,7 %) were treated for infertility, which was statistically different (p<0,05) from the data of the control group, in which only 2 women (6,7 %) received treatment for infertility. Among the relatives of women of the studied group were people with loss of hearing and speech. That was the sister of the woman with primary infertility. And the husband’s sister of the couple with infertility suffered from Down syndrome that is statistically different (p<0,05) from the data of the control group, in which there were no anomalies among the relatives.