Analysis of factors affecting the treatment and curative effect of discontinuation pyeloplasty in children with hydronephrosis

Abstract

Objective To observe the therapeutic effect of discontinuation pyeloplasty in children with hydronephrosis. Analyze the factors that affect the recovery of postoperative renal function. Methods A retrospective analysis was performed on 125 children with hydronephrosis caused by unilateral ureteropelvic junction obstruction from January 2014 to December 2015 in Hunan Children′s Hospital. Preoperative and postoperative renal pelvis anteroposterior diameter, renal parenchymal thickness, segmental artery resistance index, glomerular filtration rate (GFR), blood urea nitrogen, serum creatinine and other indicators were observed. The measurement data were expressed as mean±standard deviation (Mean±SD), and paired t-test was used for inter-group comparison, and Chi-square test was used for inter-group comparison of counting data. Logistic regression analysis was performed on the factors such as sex, age, hydronephrosis location and hydronephrosis degree before operation, and the important factors affecting postoperative renal function recovery were screened out. Results Postoperative renal pelvis anteroposterior diameter (1.87±1.02) cm, renal parenchyma thickness (6.34±1.41) mm, segmental arterial resistance index (0.68±0.05), GFR (40.54±3.25) ml/min, blood urea nitrogen (2.18±1.24) mmol/L and serum creatinine (27.54±6.21) μg/ml and other indicators were better than preoperative, the difference were statistically significant (P 0.05). Conclusions Pyeloplasty is good for children with hydronephrosis, it can improve the degree of patients with hydronephrosis, improve renal function recovery. Preoperative patients with age, degree of hydronephrosis and sub-renal function levels affect postoperative renal function recovery. Key words: Child; Hydronephrosis; Surgical procedures, operative; Ureteropelvic junction obstruction