ANALYSIS OF EXPEDIENCY TO USE PLATELET-ENRICHED PLASMA FOR TREATMENT OF ANDROGENETIC ALOPECIA

Abstract

A detailed analysis of the published data on the use of platelet−enriched plasma for the treatment of androgenetic alopecia has been performed. Based on the results, it has been suggested that platelet−rich plasma may be considered as a new treatment for pathological hair−related conditions, including androgenetic alopecia. Information on platelet morphology, characteristics of biologically active substances released from activated platelets have been provided. It has been substantiated that platelets play a crucial role in hemostasis and tissue regeneration by stimulating the cell chemotaxis, proliferation, differentiation, angiogenesis and deposition of the extracellular matrix. Among the many active components of platelets involved into the recovery of damaged tissue, the growth factors have been particularly noted. The influence of growth factors on the regulation of hair growth cycles has been established. Based on the analysis of their biological effects, the diversity of their action in the regulation of hair growth has been emphasized. Characteristic features of some growth factors, insulin−like growth factor (IGF), have been determined and described, their role in damaged tissue repair, angiogenesis, proliferation and cell differentiation has been noted. The practical experience of application of platelet−enriched plasma in various branches of medicine is summarized, proposals concerning the use of this method as a new way of treatment of androgenetic alopecia have been provided. The question of standardization of this method, study and substantiation of differentiated use of platelet−enriched plasma depending on the stage of androgenetic alopecia in men and women remains debatable. Key words: androgenetic alopecia, platelet−enriched plasma, platelets, growth factors.