Analysis of erythropoiesis indicators in HIV-infected persons and patients with HIV/TB co-infection depending on anemia severity level

Abstract

The aim of the work was the analysis of erythropoiesis (EP) in HIV-infected persons and patients with HIV/TB co-infection depending on anemia severity.Methods of research: the study included 124 patients (62 patients with HIV-infection and 62 patients with HIV/TB co-infection). The control group included 32 practically healthy donors. All patients underwent the determination of anemia severity and erythropoiesis indicators.Results. HIV-infected persons with anemia of III severity degree has erythropoietin (ERO) content 14,3 ± 1,5 iUn/ml that is essentially lower than in the control group and comparison group (рl0,001). ERO content in blood serum of patients with HIV/TB co-infection with anemia I, II and III is essentially higher (135,8 ± 38,7, 203,7 ± 58,3 and 330,1 ± 127,2 iUn/ml) respectively against the same value in the control and main groups (23,7 ± 1,12 iUn/ml and 21,4 ± 1,89 iUn/ml, р l0,001) – in 8 times.Conclusions. The analysis of erythropoiesis indicators revealed the reliably low level of erythropoietin in patients with HIV-infection at severe anemia compared with the control group and patients with HIV/TB co-infection and the reliably high erythropoietin level in patients with HIV/TB co-infection at middle and severe anemia compared with the control and main groups