Abstract
Protein C (PC) is a glycoprotein that plays a pivotal role as an anticoagulant, antithromobotic, and thrombolytic therapeutic in the blood coagulation cascade (Esmon, 1989). It is a member of the vitamin K-dependent (VKD) family also consisting of coagulation protein factors VII, IX, X, proteins S, Z and prothrombin. Human PC is synthesized in the liver as a single chain precursor and circulates in the blood primarily as a two chain zymogen that is activated by proteolytic clevage. Activated PC is a potent serine protease that regulates blood coagulation by deactivating factors Va and VIIIa (a: activated form), thus preventing generation of the enzyme factors Xa and thrombin (Wu and Bruley, 1999).KeywordsDeep Vein ThrombosisImmobilize Metal Affinity ChromatographyEquilibrium Adsorption IsothermBlood Coagulation CascadeMaryland Baltimore CountyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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