Abstract
AbstractA 45‐year‐old woman had a triple cancer, multiple Bowen's disease, breast cancer, and carcinoma in situ of the cervical portion of her uterus. Development of all three carcinomas was discovered within a period of three years. Southern blotting analysis of the epidermal growth factor receptor (EGFRc) gene of DNA extracted from the individual lesions of multiple Bowen's disease revealed no amplification or variant other than one extra band observed in one lesion. DNA extracted from other patients with solitary Bowen's disease showed essentially the same result. In contrast to squamous cell carcinoma DNA which sometimes has amplification of this gene, our present case suggests that there is only a small possibility that the EGFRc gene plays a role in the carcinogenesis of Bowen's disease.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
