Abstract

The zebrafish (Brachydanio rerio), a small fresh water fish native to rivers of northeast India, has long been a favorite of tropical fish fanciers. Within the past few years, it has also become an organism of great interest to vertebrate embryologists. The potential of the zebrafish as an effective experimental system can be traced to the work of G. Streisinger who recognized that the organism was highly suited to genetic analysis (Streisinger et al. 1981). After his untimely death, the development of the system was continued at the University of Oregon, and more recently, at many laboratories in the United States and Europe. The result has been a productive investigation of the embryology, genetics, neurobiology, and molecular biology of the zebrafish embryo (reviewed most recently in Kimmel and Warga 1988; Kimmel 1989; Ekker and Akimenko 1991; Fulwiler and Gilbert 1991). In this review, I will attempt to summarize what is known about the early development, genetics, and molecular biology of the zebrafish. Development of the nervous system has been more intensively investigated than any other aspect of embryogenesis in this organism. This subject has been reviewed recently (Eisen 1991) and will not be covered in detail here.

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