Abstract
Aim. To study the level of anti-diphtheria antitoxic antibodies in blood serum of vaccinated individuals over the period of 2015-2017.
 Materials and Methods. The study was conducted on the base of the Center of Hygiene and Epidemiology of the Ryazan region. The evaluation of antitoxic immunity against diphtheria was performed on the basis of the results of annual serological examination of at least 100 samples of blood sera for the content of diphtheria antitoxin in each age indicator group. In the study reaction of passive hem agglutination was used with standardized erythrocyte diphtheria antigen. Blood serum samples of individuals of indicator groups of the population with a documented history of vaccination were investigated. On the basis of the results of serological monitoring, the analysis of the state of anti-diphtheria antitoxic immunity in children (3-4 years, n=300), teenagers (16-17 years, n=302) and adults (30-39 years, n=323; 40-49 years, n=305) of the Ryazan region in 2015-2017 was carried out.
 Results. The level of protection among children, teenagers and adults in the studied period was 97.0 and 95.6%. The intensity of anti-diphtheria immunity was also high: 93.3-95.6% of the examined persons had medium and high antibody titers. Protective level of anti-diphtheria antibodies in 2015 was revealed in 97.3%, in 2016 in 93.3% and in 2017 in 98.3% of the examined samples.
 Conclusion. Analysis of the results of serological monitoring showed a positive dynamics of growth of the number of seropositive individuals with intense anti-diphtheria immunity. The data of serological monitoring correspond to the official statistical data of Directorate of Rospotrebnadzor in the Ryazan region on the high level of coverage of the population with vaccination. According to previously published epidemiological studies, in such conditions the incidence of diphtheria in the population is sporadic.
Highlights
The work was conducted in accordance with Methodical Instructions МU 3.1.2943-11 on «Organization and Conduction of Serological Monitoring of Community Immunity against Infections Managed by Means of Specific Prophylaxis» which defines individuals as protected from these infections if their blood serum contains antitoxic antibodies in the titer 1/20 and higher [5]
In children of 3-4 years the protective level of antitoxic anti-diphtheria immunity was found in 96.0%, in teenagers of 16-17 years – in 99.0% with 1/320 and higher titers in 57.0 and 87.0% of them, respectively
In the group of 40-49 years the protective level of antitoxic anti-diphtheria immunity was found in 83.0% of individuals, 49.0% of them had 1/320 and higher titers
Summary
Изучение уровня противодифтерийных антитоксических антител в сыворотках крови привитых лиц за период 2015-2017 гг. Оценка антитоксического иммунитета против дифтерии была сделана на основании результатов ежегодного серологического исследования не менее 100 проб сывороток крови в каждой возрастной индикаторной группе на содержание дифтерийного антитоксина. По результатам серологического мониторинга проведен анализ состояния противодифтерийного антитоксического иммунитета у детей (3-4 года, n=300), подростков (16-17 лет, n=302) и взрослого населения (30-39 лет, n=323; 40-49 лет, n=305) Рязанской области в 2015-2017 гг. Напряженность противодифтерийного иммунитета также была высокой: 93,3-95,6% обследованных лиц имели средние и высокие титры антител. Анализ результатов серологического мониторинга показал положительную динамику роста количества серопозитивных лиц, имеющих напряженный противодифтерийный иммунитет. Данные проведенного серологического мониторинга соответствуют официальным статистическим сведениям Управления Роспотребнадзора по Рязанской области о высоком уровне охвата населения прививками. Согласно опубликованным ранее данным эпидемиологических исследований, в таких условиях заболеваемость дифтерией в популяции носит спорадический характер
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