Analysis of distribution and antibiotic resistance of pathogens in lower respiratory infection

Abstract

Objective To investigate the distribution and antibiotic resistance of pathogens in the patients with lower respiratory infections in our hospital. Methods Bacterial culture was preformed from sputum specimens of diagnosed patients with lower respiratory infections in our hospital. Bacterium's appraisal and antimi-crobial susceptibility test for positive specimens were preformed by the Microscan A/S-4 semi-automatic bacteria of America's spirit company and drug susceptibility analyzer and its supporting identification and drug susceptibility plate. Results Gram-negative bacilli were the major microorganism in bacterium. The top 5 pathogens are Pseudomo-nas aeruginosa, pneumonia crayresearch bacteria, baumanii/haemolyticus, Xanthomonas maltophilia and Escheri-chia coli. Drug sensitive experiments showed the resistance rate of gram-negative bacteria to broad-spectrum antibi-otics was increased. Drug resistance rate of pseudomonas aeruginosa against Ceftriaxine, pneumonia crayresearch bacteria and colon bacillus against penicillins and cephalosporin and Ammonia Qu Na was above 60%, 80% and 50% respectively. The resistant rate of Baoman/hematolysis bacillus to the majority antibiotics is above 70%, which of Xanthomonas maltophilia to cephalosporins, quinolones and aminoglycosides were above 90%. Coagulase-negative staphylococcus as the core of Gram-positive bacteria, the resistant rate to Penicillin and cephalosporin are above 85%. The resistance rate of staphylococcus to the majority antibiotics was comparatively low. Conclusions More attention should be paid on distribution and diversify of bacterium in lower respiratory infections clinically and rational use of antibiotics. Key words: Respiratory infection; Pathogenic bacteria; Antibacterial