Abstract
We investigated the association between HLA class II alleles and severe atopic dermatitis with high serum IgE levels (greater than 8000 U/ml). The frequencies of HLA-DRB1*1302 and DQB1*0604 were increased, whereas the frequency of HLA-DQB1*0302 was decreased. A strong haplotype, HLA-DRB1*1302-DQB1*0604, has been reported in the Japanese population, and this haplotype is conserved in patients with AD. Further analysis of the amino acid epitopes on the HLA-DRβ1 and DQβ1 domains revealed that DRβ1 71 Glu (RR = 5.71, p < 0.05) and DQβ1 30His (RR = 3.25 p < 0.01), and 57Val (RR = 3.13, p < 0.05) were increased in frequency. DRβ1 71Glu was exclusively unique to DRB1*1302. DQβ1 30His was shared by the following alleles: DQβ1*0501, *0502, *0503, and *0604, which were all increased in patients with AD. DQβ1 57 Val was shared by DQB1*0501 and *0604. A well-known haplotype, HLA-DRB1*1302-DQB1*0604, contains DRβ1 71Glu and DQβ1 30His and 57Val. Therefore HLA-DRβ1 71Glu and/or DQβ1 30His/ 57Val are considered to play the most important role in the development of atopic dermatitis. (J A LLERGY C LIN I MMUNOL 1995;96:1061-8.)
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