Abstract
The absorption characteristics of the dermis were reviewed in the terahertz range from 0.2 to 2 THz. The absorption magnitude of the dermis was higher than that of the epidermis model owing to the inclusion of collagen fibers. The heat denaturation of the collagen and the decrease of water content in the dermis caused a decrease in the absorption magnitude of the dermis. We verified that the absorption magnitude of collagen sheets at 1 THz similarly decreased by nearly 43% upon the heat treatment at approximately 70° C. When the heat-treated sheet was used as a scaffold for cell culture, the average growth rate of the fibroblast increased. These findings suggest that variation in the ability of cell growth in the dermis can be predicted using the absorption of the collagen or the difference between the absorptions of dermis and water.
Highlights
Nondestructive testing using terahertz waves with frequencies from 0.1 to 10 THz is an emerging technology in science and industry for evaluating the properties of a material or component [1, 2]
The absorption characteristics of the dermis were reviewed in the terahertz range from 0.2 to 2 THz
The absorption magnitude of the dermis was higher than that of the epidermis model owing to the inclusion of collagen fibers
Summary
Nondestructive testing using terahertz waves with frequencies from 0.1 to 10 THz is an emerging technology in science and industry for evaluating the properties of a material or component [1, 2]. When we employ the dermis models or the cultured dermal-cell tissues used for the evaluation of environmental exposure, we must evaluate the sample using various parameters such as water content, collagen state, and cell growth rate to verify the variation in the biological state of the samples used. Terahertz spectroscopy allows us to observe the higher-order structure of biological tissues or complex interactions between large molecules, which may be a measure of the composite conditions in dermal samples [15]. If terahertz spectroscopy can analyze water content and collagen conditions separated from dermal composite condition, and can predict a biological activity, such as the ability of cell growth, the spectroscopic method would be more useful for evaluating the samples used in environmental exposure studies. The results suggest that we can distinguish variations in the cell growth ability from the terahertz absorption of collagen before cell growth
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
