Analysis of demographic and staging characteristics in patients with colorectal cancer using the SEER registry.

Abstract

e15589 Background: Screening for colorectal cancer (CRC) has traditionally begun at age 50, with more recent guidelines suggesting beginning at age 45 to enhance earlier detection. Methods: Incidence data of CRC from the NCI’s Surveillance, Epidemiology, and End Results (SEER) Program 21 registry was utilized for this study. This study analyzed data from 2014-2018 with 95% confidence intervals for ages 50-64, 64-74, and 75+. Localized, regional and distant metastasis were coded according to the SEER database. Results: The incidence of CRC increased with age as individuals ages 75+ had the highest incidence at 211.8 per 100,000, compared to 70.7 for ages 50-64. In the age group of 75+, the incidence of localized CRC was 70.1 (95% CI: 69.2-71.0) and regional CRC was 69.2 (68.4-70.1) which was not statistically significant. Upon analyzing sex in CRC, female patients have a statistically lower chance of presenting with CRC at 59.5, 107.6, 192.1 for the age groups 50-64, 65-74, and 75+ respectively, whereas male counterparts have rates of 82.7, 152.9, and 240.2. Analysis of Asian females showed no difference in incidence of local and regional disease for ages 50-74. For ages 75+, the incidence of regional disease at 54.6 (51.3-58.1) was much higher than local disease at 45.3 (42.3- 48.5). Of note, Asian females aged 50-64, Hispanic females ages 65 and older, and Black and White females ages 75+ were equally likely to present with local or regional disease. White males had statistically significant higher odds of localized compared to regional cancer in all age groups. Further analysis shows that Asian males have an equal incidence of local and regional disease for ages 65 and above. Black males ages 75+ and Hispanic males ages 50+ had a similar incidence of local and regional CRC. Conclusions: Ensuring equitable access to screening and earlier screening may be beneficial and improve cancer-related mortality in certain demographics. A more modern data set should be analyzed to support these findings. This analysis was limited to incidence of CRC, and future studies assessing presentation at diagnosis could be insightful.[Table: see text]