Analysis of CTLA4 gene 49A/G polymorphism association with development of allergic rhinitis

Abstract

CTLA4 gene 49A/G polymorphism was analyzed in 44 patients with allergic rhinitis and 70 nominally healthy donors of the Uzbek population. The unfavorable allele rate of this polymorphism in general studied groups and control groups did not differ significantly; it was 73.3 and 72.9% respectively. A comparative analysis of the distribution of CTLA4 gene 49A/G polymorphism in groups of patients with allergic rhinitis, depending on the clinical course and patient’s gender, with the control groups did not reveal statistically significant differences. However, in patients with year-round forms of allergic rhinitis, the rate of the functionally unfavorable allele 49A/G of CTLA4 gene was almost 1.29 times higher than the same rate in the group with the seasonal form and the slightly higher than the rate in the control group.