Analysis of correlation factors of MR diffusion-weighted imaging in patients with acute cerebral infarction

Abstract

Objective To explore the correlation factors of cranial magnetic resonance diffusion weighted imaging(DWI) in patients with acute cerebral infarction. Methods A total of 350 patients with acute cerebral infarction who underwent MR imaging were divided into DWI positive group and negative group according to whether the first diffusion weighted imaging was abnormal or not.The clinical and radiological data of the two groups were retrospectively collected and analyzed.patients with negative DWI on initial MRI were re-examined 1 week later. Result Thirty-four(9.7%) patients were DWI-negative in 350 patients with acute cerebral infarction on initial MRI, and 5 patients in DWI-negative group had positive lesions on the re-examine MRI.Multivariate logistic regression analysis indicated the patients with first blood pressure of admission≥ 140/90 mmHg(P=0.033), first blood glucose of admission≥ 7.0 mmol/L(P=0.028) and the time from the onset to initial MRI>24 h were more likely showed DWI-positive on initial MRI(P=0.013). Patients with posterior circulation infarcts were more likely to have negative DWI findings than patients with anterior circulation infarction(P=0.001). Conclusion Some patients with acute cerebral infarction may show DWI negative results on initial MRI, which is related with the time from onset to initial MRI and the site of cerebral infarction.Patients with posterior circulation infarcts are more likely to have first negative MR findings than patients with anterior circulation infarction.Patients with elevation of the admission blood pressure or blood glucose are more likely to have DWI positive lesions.Patients with acute cerebral infarction within the time window should received be thrombolytic therapy after carefully assessment to avoid delay in treatment even if the DWI negative results. Key words: Acute cerebral infarction; Magnetic resonance negative; Influencing factors