Abstract
Background Event-free survival (EFS) endpoints are composite endpoints frequently used in cancer gene expression studies to evaluate the effects of gene expression on patient outcomes. Event free Survival endpoints in oncology, such as Overall survival, typically combine both cancer-specific ‘death from cancer’ and non-cancer specific events ‘death from other causes’. Reporting analysis on each event comprising the composite endpoint is necessary to draw more specific inferences regarding outcomes, especially in the presence of competing risks. The extent to which cancerspecific and non-specific events are separated in contemporary gene expression studies in oncology is unknown.
Highlights
Event-free survival (EFS) endpoints are composite endpoints frequently used in cancer gene expression studies to evaluate the effects of gene expression on patient outcomes
The extent to which cancerspecific and non-specific events are separated in contemporary gene expression studies in oncology is unknown
Increased specificity is required in the design and reporting of cancer gene expression studies
Summary
Analysis of composite endpoints in gene expression studies in oncology Background Event-free survival (EFS) endpoints are composite endpoints frequently used in cancer gene expression studies to evaluate the effects of gene expression on patient outcomes. Event free Survival endpoints in oncology, such as Overall survival, typically combine both cancer-specific ‘death from cancer’ and non-cancer specific events ‘death from other causes’. Reporting analysis on each event comprising the composite endpoint is necessary to draw more specific inferences regarding outcomes, especially in the presence of competing risks.
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