Year-end Sale % OFF 
Abstract
Size-diversity of lg and T cell receptor antigen binding (CDR3) regions can be visualized by “CDR3 fingerprinting”, and provides an estimate of B- or T-cell repertoire complexity. The method does not identify clonal diversity, however, which can only be determined by random sequencing of the CDR3s. In this study we demonstrate that a combination of fingerprinting and single strand conformation polymorphism (SSCP) analysis can be used for a rapid estimatation of clonal diversity within mouse lg antigen binding regions selected for size. This application may be useful in the analysis of clonal expansion within B- and T-cell repertoires.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
