Analysis of clinicopathological features of 21 patients with enteropathy-associated T-cell lymphoma

Abstract

Objective To investigate the clinicopathological and prognosis features of enteropathy-associated T-cell lymphoma (EATL). Methods 21 cases of EATL, 6 cases of peripheral T-cell lymphoma (PTCL) and 11 cases of natural-killer/T-cell lymphoma (NKTCL) were collected from January 2008 to May 2015. The immunophenotype of the tumor cell was tested by EnVision and as well as EBV-EBER for EB virus. Some patients were performed with follow-up data. Results 21 EATL patients included 14 males, 7 females and the middle age was 55 years old (40-79 years old). 15 patients affected the small bowel, 4 cases affected colon, 2 cases affected more than one site. 18 cases were mono-morpholohic EATL while 3 cases were classical EATL. The expression rates of neoplastic cells for CD3e, CD4, CD8, CD56, Granzyme B, TIA-1 were 95.24 % (20/21), 20.00 % (3/15), 73.68 % (14/19), 85.71 % (18/21), 64.71 % (11/17), 88.89 % (16/18) respectively. The expression of EBER in EATL patients (0, 0/21) was obviously lower than that in NKTCL patients (100 %, 11/11). 17 EATL patients had follow-up data, and the middle survival time was 15 months. No different prognosis was found in the three kinds of T-NHL (P = 0.697). Conclusions EATL usually occurs in elder male and jejunum. The diagnosis of EATL needs a lot of information, including clinical history, endoscopy, histomorphology, immunophenotype and EBV-EBER result. EATL has low mobidity and high malignancy, it still lacks impactful therapeutic regimen. Key words: Enteropathy-associated T-cell lymphoma; Pathology, clinical; Immunophenotype; Natural-killer/T-cell lymphoma