Analysis of clinical outcome of IVM-IVF-ET and IVF-ET cycles

Abstract

In vitro maturation (IVM) protocol appears to be a potential treatment for infertility as it is relatively simple, with shorter period of treatment and minimal hormone injections to patients. Moreover, the side effects of stimulation for OHSS are eliminated and it is cost effective compare to the conventional in vitro fertilization (IVF) protocol. This study was performed to evaluate two protocols, IVM and conventional IVF. The implantation, pregnancy and abortion rates were evaluated. Retrospective study. The clinical outcome of 270 IVM-IVF-ET cycles and 9022 conventional IVF-ET cycles undertaken in the CHA Fertility Center from 2006 to 2009 were analyzed retrospectively. Patients with age of 39 and under were included in IVM group, hence; the same age group was selected for IVF in order to compare both groups. A total of 270 IVM-IVF-ET cycles (IVM group) and 9022 conventional IVF-ET cycles (IVF group) were applied in the study. The pregnancy rate of IVM group was 37.78% (102/270) and 41.39% (3734/9022) in IVF group. There was no significant difference between both groups. The implantation rate of IVM group was slightly lower compare to the IVF group, 16.96% (133/784) and 20.77% (5246/25253) (P<0.05), respectively. Moreover, among the pregnancy cycles with follow ups, the abortion rate was 31.91% and 22.70% in IVM and IVF groups, respectively. There was no significant difference in both groups. In pregnancy cycles, 55 cases and 1342 cases did not follow up in IVM and IVF groups, respectively. From our results, the IVM protocol showed slightly low implantation rate than conventional IVF protocol. However, there was no significant difference in the pregnancy and abortion rates in both groups. Hence, the IVM protocol for immature oocytes could be a promising potential treatment for selected patients.